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3 The early recognition of deterioration and the starting of therapy in PACU can prevent these complications or reduce their severity.
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One RCT regarding timing of hemofiltration (defined as the time between ICU admission and start of therapy) was negative [69].
Scr: serum creatinine; Clcr: creatinine clearance; EOT: end of therapy, SOT: start of therapy.
FDG-PET/computed tomography (CT) scans were obtained at baseline (up to 2 weeks prior to start of therapy) and at day 14 (±1) from start of therapy.
Start of therapy was determined as the beginning of cardiopulmonary bypass.
Abdominal and chest CT scans must be done within 4 weeks prior to start of therapy.
Prior to start of therapy a percutaneous endoscopically controlled gastrostomy (PEG) was given to all patients.
*ACT, artemisinin-based combination therapy; ATS, artesunate; MFQ, mefloquine; day 0, first 24 h of enrollment and start of therapy.
One RCT regarding timing of hemofiltration (defined as the time between ICU admission and start of therapy) was negative [ 69].
The disease is rapidly progressing; there is a need for urgent diagnostic work-up and start of therapy.
In symptomatic patients, however, the yield of reducing time between onset of symptoms and start of therapy in terms of improved survival is controversial.
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