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Starting dosing late contributes to non-compliance, so we felt it was important to include hospitalizations that occurred prior to initiation of palivizumab prophylaxis in the analysis.
Therefore, we would recommend starting dosing with lower doses of each drug (e.g. capecitabine 1000 mg m−2 twice daily; docetaxel 60 mg m−2), which have been proven to be effective in various combination regimens.
Our results suggest that tacrolimus starting dosing guidelines in children should reflect both age and CYP3A5 genotype to reduce the time needed to reach therapeutic concentrations directly after transplant.
As per the SPC for OLAI [ 14] a sensitivity analysis was also run examining the cost effectiveness of a 210 mg/2 weeks starting dosing (keeping the maintenance dose equivalent to 300 mg/4 weeks) schedule and was found to have a negligible impact on the results (see Table 8).
In the 1-h schedule, the dose of PM00104 was escalated by increments of 100%50%0% if grade 2 toxicity occurred, and 25% if grade 3 or 4 toxicity occurred), while in the 3-h schedule, in view of the higher starting dosing, doses were escalated by increments of 25%.
Similar(55)
A drug sold at an underperforming starting dose would, of course, be at a disadvantage.
Merck could also include doses of fifteen and twenty milligrams, for people who tried the starting dose and found it unhelpful.
The letter encouraged the company to revise its application, making ten milligrams the drug's starting dose.
A safe dose, determined from testing in animals, is used as the starting dose.
The starting dose was 2.5 mg.
The starting dose of 90Y-Zevalin is 0.08 mCi/kg.
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