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The starting dose for this plateau is 2.5 mg zolmitriptan.
With good intention, it was proposed to use the results of cytotoxicity testing to determine the starting dose for acute oral toxicity testing.
However, the data obtained from such methods cannot be directly extrapolated to humans and often do not provide a safe starting dose for first-in-human studies.
Although the drug exposure in humans can be reasonably predicted for mAbs with linear PK above saturation dose, prediction of drug exposure at low starting doses for mAbs (typically starting dose for dose escalation study) is challenging and generally poor because of nonlinear PK (Dong et al., 2011).
The starting dose for both viruses was 6×109 vp/mouse, corresponding to 8.8×108 pfu for Ad5WT, slightly lower than the published maximum tolerated dose (MTD, 1×109 pfu) [17].
The starting dose for HCQ was 200 mg daily.
The starting dose for both insulins was 10 units.
The recommended starting dose for this study was 1 μg/kg/min.
The starting dose for all patients was erlotinib 150 mg orally once daily for 21 days.
The recommended starting dose for all patients was 25 mg given intramuscularly every two weeks [ 9].
The initial starting dose for the protocol was 160 IU m−.
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