Exact(4)
This obviously depends however on the quality and comprehensiveness of the gene predictions in our starting datasets.
In most of these cases the fragments still clustered with other eLRR genes and a full-length sequence was often identifiable from one of the starting datasets.
Methods are evaluated based on their ability to reconstruct the GO from two starting datasets: (a) pairwise semantic similarities, which are derived directly from GO itself, and (b) three different -omics datasets (genetic interaction profile correlation, gene expression correlation and an integrated -omics dataset for yeast).
We evaluated the robustness of our results considering different starting datasets (5000 and 7000 top-scoring probes) and different parameters for clustering (chromosomal distance threshold from 20 Kb to 35 Kb, see below) obtaining a good agreement in the final SNP lists.
Similar(56)
The starting dataset with all input data combined and the data processing code file for inter/extrapolation and for index construction are available at Data Citation 1: figshare https://doi.org/10.6084/m9.figshare.org/10.6084/m9.figshare
It is to be expected that comparative approaches will tend to underestimate the components of any given complex, since the approach is dependent upon the starting dataset.
The third dataset, D p, is identical to our starting dataset.
The output file after this step served as the starting dataset for the indel RNA editing analysis.
iNMF is robust with respect to the starting dataset and can be applied to identify inherent disease subtypes.
The starting dataset comprises all putative regulatory interactions found within the genomes of the thirty gamma-proteobacteria included in the database.
We hope this report would also provide a much needed starting dataset for experimental biologists for validating and elucidating potential molecular mechanisms.
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