When nuclear Mdm2 level gets beyond its threshold KP, it starts to inhibit p53 activity (domain D23).
Involuntary attention is a bottom-up (stimulus-driven) process [ 19] but during maturation the developing top-down mechanisms start to inhibit distractors which are not meaningful, in other words, children learn to separate relevant from irrelevant stimuli [ 20, 21].
In addition, we found that GM-CSF Ab levels in serum samples of patients with IBD who had no clinical disease relapse during the study follow-up showed a low intra-individual variation and GM-CSF Ab levels were below the cut-point where GM-CSF Ab start to inhibit neutrophil antibacterial function [30].
As soon as the auxin concentration in cell 2 exceeds the threshold for auxin-dependent PIN1 degradation (q 3), auxin starts to inhibit PIN1 expression.
As illustrated in Figure 5, 6 μM of Jac-A treatment started to clearly inhibit the binding of Bcl-xL and Bax.
However, due to the presence of (area-specific and local) inhibitory circuits, the different HNCs simultaneously activated will start to reciprocally inhibit each other, in a 'winner-takes-all' fashion.
At this time point, sunitinib started to lose its ability to inhibit p70S6K and MAPK phosphorylation and hVEGF secretion while, conversely, induced a 5-fold increase in IL-8 levels.
PR typically start to be inhibited at six months [ 21] and their presence is used to assess CNS integrity [ 23].
Interestingly after 48 hours of culture the number of mitotic cells decreases significantly, in a similar amount, both in 1 g and in RPM cultured samples, indicating that cell proliferation, in this particular cell line, starts to be inhibited by cell-to-cell contact even if these cells are cancer cells.
