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Moreover, eight patients started the study protocol after achieving clinical response to previous trastuzumab combination therapy.
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Each subject gave written informed consent before starting the study protocol which was approved by the Human Research Committee of the Partners HealthCare System, and was in accordance with the Declaration of Helsinki.
Duration of mechanical ventilation before starting the study protocol was 26 hours (range, 6-60 hours).
An informed consent and medical screening was completed before starting the study protocol.
If blood glucose was too low, patients would not start the study protocol and were asked to return another day.
Before the start of the study protocol, a suction catheter was inserted blindly into the tracheal tube until it reached mechanical resistance.
Before the start of the study protocol blood glucose was measured by finger prick (OneTouch Ultra; Lifescan, Milpitas, CA).
At the start of the study protocol, two baseline measurements were performed in each patient, 30 min apart.
Figure 1 shows the averaged blood glucose values from the start of the study protocol until the end of the study day per treatment arm.
The cuff of the endotracheal tube was transiently overinflated to 60 cmH2O before the start of the study protocol to prevent air leaks.
Weaning from the ventilator was started after completion of the study protocol.
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