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Overall survival was defined as time from treatment start to death from any cause, or last follow-up date.
Progression free survival (PFS) was defined as time from treatment initiation to first documentation of progression or death and overall survival (OS) as time from treatment start to death.
Secondary end points included: response duration (first determination of CR or PR to progression), disease control rate (DCR; the sum of CR and PR and stable disease (SD), OS (treatment start to death), TTP (treatment start to progression), and PFS.
OS was defined as the time from treatment start to death due to any cause; patients lost to follow-up or who were still alive at analysis cut-off date were censored at their last contact date.
Overall survival was defined as the elapsed time from treatment start to death from any cause with follow-up for surviving patients censored at the date of last contact.
Time to progression (TTP) was calculated from date of therapy start to progression or last follow-up date; overall survival (OS) was calculated from the date of therapy start to death or last follow-up date, with 95% confidence intervals calculated using the Kaplan Meier method (Kaplan and Meier, 1985).
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Companies with flawed business models and those that are mismanaged will start to enter death spirals and either be bought or go out of business.
Whatever the cause of death in this case, we should not be surprised if, as the outbreak grows, we start to see deaths in Wales".
Survival was calculated from the day of treatment start to the end point (death or censoring).
Overall survival was measured from the time treatment started to date of death resulting from any cause.
It gets stuck in the kid's windpipe, and he starts choking to death.
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