Fortunately, newer random-start stimulation protocols can be initiated in the follicular or luteal phase, reducing the length of time to oocyte retrieval and minimizing treatment delay [22].
Subjects started stimulation with a single s.c. injection of 150 µg (0.5 ml) corifollitropin alfa (Elonva®, N.V. Organon, The Netherlands).
Eventually, 1509 patients were randomized to one of the two treatment groups of which 1506 patients actually started stimulation.
In brief, patients were down regulated with Lupron and started stimulation on day 3 with r-FSH (Gonal-F, Sereno).
The daily dose of HP-uFSH was adjusted 5 days after starting stimulation depending on follicular development as observed by ultrasonography and serum estradiol.
Patients started stimulation with a single s.c. injection of 150 µg (0.5 mL) corifollitropin alfa (NV Organon, The Netherlands) or matching placebo.
Fatigability of the muscles was measured by calculating the percentage decrease in force between the start of stimulation (F0s) and the end of stimulation (F300s).
Cognitive tasks were initiated 5 minutes after the start of stimulation as it has been shown that 3 minutes of stimulation is the minimum duration of stimulation in order to induce significant after-effects changes in the cortical excitability [26].
Secondary endpoints included pain freedom at 15 minutes following the start of stimulation, pain relief and pain freedom at 30, 60, and 90 minutes after initiating stimulation, and reduction in acute medication.
This article evaluates the efficiency of random start ovarian stimulation in affected women.
