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If no clinically relevant STOPP or START outcomes were present, the drug treatment was considered appropriate.
The proportion of START outcomes being clinically relevant was greater in control than in MDD patients.
For START outcomes, the corresponding figures were 45 out of 157 (28.7 %) and 36 out of 93 (38.7 %), respectively.
Then the clinical relevance of identified STOPP and/or START outcomes was assessed at the individual level.
In order to keep a conservative approach to categorizing drugs as inappropriate or missing, we chose to categorize STOPP and START outcomes not possible to assess concerning clinical relevance as not clinically relevant.
In order to keep a conservative approach to categorizing drugs as inappropriate or missing, we chose to categorize STOPP and START outcomes not possible to assess concerning clinical relevance (e.g., due to missing information) as not clinically relevant.
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A missing drug was defined as a clinically relevant START outcome.
Correspondingly, overtreatment was defined as ≥1 clinically relevant STOPP outcome (≥1 inappropriate drug) and undertreatment as ≥1 clinically relevant START outcome (≥1 missing drug).
Suboptimal drug treatment was defined as ≥1 STOPP or ≥1 START outcome assessed as clinically relevant after individual considerations had been made.
Thus, if there was a clinical reason not to treat the patient with the drug, such as an adverse drug reaction or a contraindication, the START outcome was assessed as not clinically relevant, i.e., not representing a missing drug.
What about Head Start's outcomes?
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