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We take into account a guard time of 1 s (which is five times more than needed according to our calculations) at the start of this phase to compensate the clock drift during 2 h.
Recently and well after the design and start of this phase III study, the FDA issued a statement on the use of patient-reported outcome measures in the evaluation of therapeutic efficacy of drugs for medical conditions, in general, and irritable bowel syndrome, in particular.
At the start of this phase I combination study of BMS-188797 and cisplatin, the phase I single-agent trial investigating 3-weekly treatment intervals was still actively recruiting patients at the 175 mg m−2 DL, and the interim analysis suggested that BMS-188797 80–100 mg m−2 would be safe for subsequent combination studies.
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The speaker for each phase was always announced before the start of the phase and remained the same throughout the phase.
There was also no significant difference in AER assessed at the start of phase 2 and phase 5, indicating absence of an order effect.
There are good reasons to base the calculation of the degradation rate in phase 2 on equation 2, i.e. not to include the remaining TOC from phase 1 in the evaluation of phase 2. Let us assume that the first degradation reaction has reached the plateau phase at the start of phase 2. In this case, any remaining TOC is not further degradable.
So in conclusion, today is the start of a new phase of this case, a phase where we'll get review by a higher court.
You may need to wait several weeks or months after acute injury to start this phase of repair.
Live-cell confocal imaging of wild type mouse oocytes microinjected with H2B-mCherry and GFP-MCAK showed that MCAK accumulates at MTOCs and on microtubules during phase 1 but does not appear at kinetochores until chromosomes congress on the surface of the ball at the start of phase 2. This event is accompanied by an increase in Sgol2's abundance at kinetochores and by phosphorylation of T521.
Shortly after the start of this clinical trial, in a phase I and a phase II trial of cisplatin and paclitaxel combined with ifosfamide, significant activity against ovarian epithelial cancer was noted.
Assessments occurred at 'study entry' (start of Phase I), 'baseline' (start of Phase II), '6 months' (post-test) and will occur at '12 months' (follow-up; primary endpoint).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com