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Interleukin-6 (IL6) and fibrinogen were measured at the start of study.
The remainder had received their last BoNT/A injection a median 15.7 weeks (range 12 171 weeks) before start of study.
c At start of study.
In both models the animals were 6 weeks of age at the start of study.
Baseline tumour assessments were performed no more than 4 weeks before the start of study treatment.
The mean ± SD level of TC at the start of study was 5.2 ± 1.7 mmol/L.
Tumour progression had to be demonstrated within 6 weeks before the start of study treatment.
AEs with onset (or worsening) after the start of study drug were considered treatment-emergent.
The mean ± SD level of DBP at the start of study was 77.2 ± 12.0 mm Hg.
The first evaluation with imaging was performed 6 weeks after the start of study treatment.
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Median lead time from initial diagnosis to start-of-study therapy was 52 days (range 1 118 days).
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