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A Hoffman 3D brain phantom was filled with 20 MBq of 18F solution (FDG) at the start of scanning and scanned in a list mode or dynamic mode for 30 min together with a cylindrical phantom containing 80 MBq of 18F solution (FDG) placed on the bed 30 cm apart from the end of the phantom simulating the body activity.
The delay from start of contrast material injection to start of scanning was planned using the bolus-tracking technique.
In the fMRI study, the practice session occurred prior to the start of scanning, out of the scanner.
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Table 2 presents the injection activity, accumulation time, and estimated brain activity at the start of scan for each PET drug that were used to derive the phantom experiment protocol proposed in this article.
Table 1 Phantom activity at start of scan and the interval to be extracted from list mode phantom data for each PET drug Hoffman phantom Cylindrical phantom Activity at scan start 20 MBq 40 MBq FDG 1800 s 865 s PiB 135 s 70 s Florbetapir 710 s 350 s Flutemetamol 255 s 180 s.
Table 2 Scanning protocols and assumed brain activity at scan start that are used to derive the phantom methods of Table 1 PET drug Standard injection activity Accumulation time Standard scan time Estimated brain activity at start of scan FDG 185 MBq 30 min 30 min 20 MBq PiB 555 MBq 50 min 20 min 3 MBq Florbetapir 370 MBq 50 min 20 min 12 MBq Flutemetamol 185 MBq 90 min 30 min 3 MBq.
Performance commenced 30 s before the start of scan acquisition and continued throughout the entire scanning period.
SUV was calculated as a ratio of voxel radioactivity concentration and injected activity (both decay-corrected towards start of scan) divided by body weight.
Research shows the brain starts to retain a pattern of scanning the world, for the positive first, not for the negative.
Volumes were positioned to cover most of the brain (in some participants, data from 1 cm of the most dorsal extent of the parietal and frontal lobes were missing), based on the information from a 13-slice parasagittal anatomical localizer scan acquired at the start of each scanning session.
Arterial blood sampling (0.1 mL) was performed during the steady-state PET acquisition in the 15O CO2 and 15O O2 gases studies (13 and 16 min after the start of the scanning) and 10 min after the start of the scanning in the 15O CO gas study (A total of five blood samplings per rat).
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