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The median survival was 11.6 months (95% CI, 9.6 to 13.6), from the start of protocol therapy.
SCA was performed on plasma samples collected at the screening visit, at 27 49 days before the start of protocol therapy, on the day 0 and weeks 1, 2, 4, 8, 12 and 16 after the start of protocol therapy.
Secondary endpoints include other (minor) morbidity, chemotherapy related toxicity, treatment completion rate, pathological response, PFS (defined as the time interval between start of protocol treatment and disease progression or death), and OS (calculated from start of protocol treatment until death).
Treatment emergent VTE was defined as VTE with onset on or after the start of protocol treatment.
The variable 'PFI' at baseline was calculated as time between last dose of prior platinum and progression before the start of protocol therapy (either PLD or trabectedin/PLD).
However, with extended follow-up over a median of ∼6 months from the start of protocol treatment, we believe that the vast majority of toxicities were captured.
Similar(51)
For subjects having received antipsychotics before the start of the protocol treatment, the preceding antipsychotics are switched to the protocol treatment during the dose adjustment period for 4 weeks, as a rule (8 weeks at maximum).
Idle: Malicious peers do not participate actively in the protocol, which amounts to a crash fault from the start of the protocol.
Observations and tests are conducted before and 8, 12, 26, 52, 78, and 104 weeks after the start of the protocol treatment (for subjects already having received antipsychotic treatment before the start of the protocol treatment, the tests and observations will also be performed upon completion of the switching from the preceding treatment to the protocol treatment).
The experimental data indicate that ECF [Na+] measured at the end of the experimental protocol (136 ± 3 mmol/L), as well as water intake measured 4 and 24 h after the start of the protocol (2.8 ± 2 ml/100 g bw and 17.5 ± 3.5 ml/100 g bw, respectively) are all within the range of the predicted values.
Any libraries with concentrations below 40 ng μl−1 (per PicoGreen assay, automated on an Agilent Bravo) were considered failures and reworked from the start of the protocol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com