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GC: Daily GC (prednisone – 11; deflazacort – 110; Prednisone change to deflazacort – 9); mean start age of GC 5.0 y (2.6 8.0); daily start dose – 0.75 mg/kg prednisone or 0.9 mg/kg deflazacort.
Because almost all liraglutide-treated patients experienced transient gastrointestinal adverse effects, start dose should perhaps have been reduced.
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A drug sold at an underperforming starting dose would, of course, be at a disadvantage.
Merck could also include doses of fifteen and twenty milligrams, for people who tried the starting dose and found it unhelpful.
The letter encouraged the company to revise its application, making ten milligrams the drug's starting dose.
A safe dose, determined from testing in animals, is used as the starting dose.
The starting dose was 2.5 mg.
The starting dose of 90Y-Zevalin is 0.08 mCi/kg.
The recommended starting dose of oral sumatriptan is 50 mg.
The starting dose for this plateau is 2.5 mg zolmitriptan.
All newborns under invasive ventilation received an opioid (sufentanil, starting dose: 0.1 μg/kg/hr) in combination with a benzodiazepine (midazolam, starting dose: 30 μg/kg/hr).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com