Data collected at the start of TNF-α-blocking therapy were age, sex, duration of disease, presence or absence of rheumatoid factor (measured by ELISA; considered positive if results showed >10 IU/ml), antinuclear antibody (tested for by immunofluorescence on Hep-2 cells), number of DMARDs previously used, and start date of TNF-α-blocking therapy.
The fatality database records eruption dates (i.e. start date of eruption as per GVP, 2013).
Start date of pregnancy was estimated as the date of birth minus gestational age in days.
ESRD vintage was calculated as (Start date of dialysis in the period of study – ESRD date).
Additionally, start dates of AB use and the development of diarrhea were compared and the diagnosis of AAD was made when the first signs and symptoms of diarrhea occurred after the start of AB use.
This file also contained related positive skin-test results, date of initial skin tests, direction of transmission, types of relationships, exposure settings, start dates of likely exposure, and information used to identify relationships (record review, routine interview, contact investigation, and isolate genotyping information).
Toxicity was assessed at 1, 2, and 3 months after the starting date of the tamoxifen dose escalation using the National Cancer Institute Common Toxicity Criteria for Adverse Events, version 3.0.
If workers anticipate the starting date of the treatment, then they could use this information to modify their behavior accordingly.
The survival time was calculated from the starting date of WBRT to the date of death or last patient contact using the method of Kaplan Meier.
4 Data collection started in 1995; we decided to use all the data available between 1995 and 2012 (the starting date of the present study).
(The starting date of his doping violations).
