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Steroid hormones that are controlled by steroidogenic acute regulatory (StAR) gene regulate sperm production.
The information provided in this study will be useful for future research on StAR gene expression in amphibian reproductive biology and the development of reproductive biomarkers.
To report the pregnancy outcome of a patient with congenital lipoid adrenal hyperplasia (CLAH) due to an 11-bp deletion of the steroidogenic acute regulatory protein (StAR) gene.
Decreased serum LH level may affect the steroidogenesis in the testis, at least in part, through the inhibition of StAR gene expression that induces part of dysfunctions of reproductive activity.
Thus, the fish StAR gene contains the same number of exons (7) and introns (6) as observed in mammals, but is approximately half the size of the mammalian gene.
The precise control of the number of initiation sites on the multifunctional core was of crucial importance to the investigation of the structure property relationship of the functional star gene carriers.
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As a first step, based on the incidence of mutations in SF1 or STAR associated with AI and 46,XY DSD, the mutation analysis of the SF1 and STAR genes was performed.
The sequences were aligned using the SeqMan program of DNA star (Gene-Codes).
Based on the mouse knockout phenotypes, mutations involving the NOBOX, DMRT4, NR5A1 or StAR genes could be associated with cyst formation, however we did not detect mutations in the coding sequences of these genes in any of the cases described here.
Amino acid changes that perturb START domain function were uncovered in defective StAR genes from CAH patients, and specific amino acids are predicted to affect cholesterol binding [ 16].
Frank is a liar, an adulterer, and a compromiser who betrays himself as much as his wife, but DiCaprio projects a natural heroic sweetness — it's in his movie-star genes — which, in this case, is at odds with the character he's playing.
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