From a functional standpoint, down-regulation of MAP3K9 by miR-34a either through direct targeting or an alternative secondary mechanism would be expected to have the same phenotypic consequences.
From a molecular standpoint, while knocking down RNF121 did not alter RIP1 ubiquitination and IKK activation, the proteasomal degradation of IκBα was impaired suggesting that this E3 ubiquitin ligase regulates this process.
From a defensive standpoint, slowing down Lawson, Hansbrough and Ellington is going to be an extremely difficult task as these three players are as skilled and seasoned as any collegiate players in the past five years.
What I do know is from an overall corporate standpoint, their ratings are down, their stock price is down, and whatever Moonves decides it will be in the context, most importantly, of those two things.
From a statistical standpoint, De Boer will go down as the second-worst boss in this grim stretch.
Those of us who care very much about the environment and who were euphoric about the Obama administration's replacement of the Bush administration, among the worst in American history from the environmental standpoint, have been let down by Mr. Obama.
From an ethical standpoint, the issue comes down to a choice between two ethical values: Justice vs. Compassion.
"It's a breakthrough from the standpoint that the investigators down there all of a sudden have 44 new cases where investigations were done," Holes said.
Finding the Flappy Bird creator in Vietnam was an idea where there could be a lot of reader interest, but the risk-reward might not make financial sense from a top-down editorial standpoint.
"From the standpoint of people who live down here, Miss America is an important event," said Michael Pollock, the editor and publisher of Gaming Industry Observer, a trade magazine published in nearby Northfield.
"We knew that from a cost standpoint, if you had to lay down 100,000 pounds of composite material by hand, it would be very expensive," said Tom Cogan, chief project engineer of the 787.
