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Argenziano and colleagues' study was also carried out in a time of very different standards of intensive care (1997), compared with all other studies that were performed in the mid to late 2000s.
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The patients in groups were identical according to the severity of disease (APACHE II), the standard of intensive care, the volume of surgery care.
Thus, despite a high standard of intensive care in Germany, there was a lack of specialists available outside working hours in most of the ICUs.
With the exception of therapeutic hypothermia, there was no further difference in the standard of intensive care treatment between the two groups.
While awaiting potential benefits from neuroprotective treatments, the standard management of intensive care patients using specifically metabolic and ionic control as well as temperature maintenance is still required to preserve the damaged brain.
The standard protocol of intensive care treatment included continuous intracranial pressure (ICP) monitoring, sedation and muscle relaxation, normothermia, mild hyperventilation and catecholamines to maintain an adequate cerebral perfusion pressure.
The standard of the intensive therapy included respiratory support, infusion therapy and sedation/muscle relaxation, and analgesia.
All patients were monitored with electrocardiography, pulse oxymetry and invasive arterial blood pressure measurement according to the current standard of the intensive care units.
Moreover, the risk of microvascular events in people with MetS or T2D can only be reduced by approximately 50% using the current standard of care (intensive treatment to reduce LDL-C, blood pressure and blood glucose) [ 5].
Patients were treated following standard operating procedures of intensive care incorporating severe sepsis bundles [ 15].
During the study, all patients remained subjected to standard-of-care of the intensive care.
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