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However, it is illustrative to consider an alternative depiction of sample relationships using the network concept of standardized connectivity.
As of today, the Allen Institute has published 1772 standardized connectivity experiments tracking axonal projections in the adult mouse brain by two-photon imaging of fluorescently labeled neurons.
Standardized connectivity (Z.K; Methods) is a quantity that describes the overall strength of connections between a given node and all of the other nodes in a network.
An iterative approach was taken, where samples having a standardized connectivity below −5 were removed [ 21].
Subsequently, samples with a standardized connectivity of less than −2.5 were removed.
A sample network was constructed to identify outlying samples with a standardized connectivity score of less than −2.5.
The dendrogram does not present any obvious outliers, but individual "D4" is called as an outlier based on a standardized connectivity test.
As seen in Figure 1C, the standardized connectivity of sample BA9_91_C is significantly lower than all of the other samples, confirming its status as an outlier in the group.
Similar(3)
For instance, if a massive transportation bill included provisions that removed the ability of NHTSA to regulate software and network connectivity in vehicles, it would significantly undermine the power of the federal government to standardize connected cars.
The reason is that these companies prioritized data collection early on — standardizing internet connectivity in their vehicles and monitoring driving behavior as soon as rubber met the road.
We acquired and analyzed diffusion-weighted images to reconstruct the anatomical connectome and we computed standardized changes in connectivity as well as group differences across time using NBS.
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