Cheson BD, Bennett JM, Kantarjian H, Pinto A, Schiffer CA, Nimer SD et al. Report of an international working group to standardize response criteria for myelodysplastic syndromes.
For example, surveys that randomly allocate symptom items across the survey and standardize response patterns could be compared with traditional surveys that include discrete disease-specific modules.
Although IWC have been useful to standardize response to treatment, functional imaging has been shown to improve detection of sites of involvement, and to provide metabolic tissue characterization [ 14].
Further, while an α assessment assumes sum of item responses, the IBS-QOL standardizes responses to a 0-100 soale, so without further study, it is not clear how the scoring algorithm relates back to a simple sum score.
Lastly responsiveness (standardized response means [SRM]), floor and ceiling effects and interpretability (minimal important change [MIC]) were analyzed.
These conclusions are similar whatever the indicator of responsiveness used: Standardized Response Mean and Effect Size, all results going in the same direction.
Abbreviations: JOQOL Japanese Osteoporosis Quality of Life questionnaire, MCIC minimal clinically important change, SD standard deviation, SRM standardized response mean, VAS visual analogue scale.
In patients achieving the MCIC, significantly larger changes was noted for all the SF-8 subscales (p ≤ 0.001 for all subscales) and the EQ-5D total score (p < 0.001) (Additional file 2).> -wrap-foot>> -wrAbbreviationseviations: JOQOL Japanese Osteoporosis Quality of Life questionnaire, SD standard deviation, SRM standardized response mean.
For the additional items, we used the standardized effect size (SES) and standardized response mean (SRM) to calculate the responsiveness characteristic of two of the additional items and the total score of the rating items.
