The standardization in prognostics metrics allows a standardized methodology to evaluate, validate, and compare different prognostics algorithm.
Box 3. Standardization of methodology for in vitro assays aside from GIA. Standardization of qPCR methodology and modeling of data across trial centers.
Improved standardization of methodology encourages more consistent use of PET across different centers and aids comparison or combination of data from multiple sites.
Currently, a major limiting factor for implementing technical review is the lack of standardization for methodology design and required controls.
Further research and standardization of methodology is needed to determine whether smoke-free legislation should be extended to outdoor settings.
I agree, but can the authors say more about how standardization of methodology design and required controls will solve this problem?
Another limitation of the comet assay, which has proved problematic in generating reproducible results between different laboratories, is the lack of standardization in methodology, interpretation, and particle preparation.
More research on patient clustering in patient evaluation is needed, as well as standardization of methodology to increase comparability across studies.
The limitations of the studies included indicate that further well-designed and conducted RCTs are required, and the standardization of methodology is recommended for future studies, to facilitate comparisons of results across trials.
Yet, criteria sets for standardization of methodology have been developed, initially by the EORTC PET study group (1999) 35 and latest with PERCIST (2009) by Wahl et al. 19, 36, applied in this study.
