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Although standardised trial information leaflets were given to all participants, women received their smear results in the usual way and this differed between and within centres.
The development and dissemination of a standardised trial, together with checklist for trial performance, will help researchers to plan trials, improve study quality and validity and enable the combination of data from separate trials.
Standardised trial methods with clinically meaningful endpoints should be adopted by all future studies to help identify optimal treatments Alopecia areata is a common condition characterised by sudden onset of patchy hair loss without signs of skin inflammation or scarring.
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The standardised test will take three hours.
These hypotheses will require standardised clinical trials with proper patient tracking and sample handling to translate these molecular targets into meaningful clinical tools.
Regardless of the extent to which the intervention was standardised, pragmatic trials should describe the intervention in sufficient detail that it would be possible for someone to replicate it, or include a reference or link to a detailed description of the intervention.
Both interventions will be undertaken following trial standardised procedures (not submitted but available from the trial team).
Despite this flexibility, standardised elements of trial, such as participant recruitment processes, were perceived as problematic to local implementation processes.
Standardised protocols and trial designs for assessing the efficacy of drugs targeted against asexual parasites 45 46 are not suitable to assess gametocytocidal drugs, where the main outcome is transmission-blocking activity rather than clinical or parasitological cure.
The results showed an effect of methylphenidate on teacher rated symptoms in the parallel group trials (standardised mean difference −0.77, 95% confidence interval −0.90 to −0.64, 19 trials, 1698 participants, fig 2).
Meta-analysis showed no significant effect in favour of the foot orthoses or insoles for either the treatment trials (standardised mean difference (SMD) -0.74, CI 95%: -1.5 to 0.03) or the prevention trials (relative risk (RR) 0.78, CI 95%: 0.50 to 1.23).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com