Even if we standardised the treated volume to the duration in hours of CPFA, since the treatment started with a low filtration fraction to be gradually increased to the target value (see online supplementary material), the first hours were characterised by a certain degree of undertreatment by design.
Considering the small size of this subgroup, it seems advisable to enroll a larger study including standardised and randomised treated patients to further validate these data.
The challenges of this study are related to standardising the interventions, treating a non-homogeneous population, defining and standardising relevant outcome measures on a population with long-lasting symptoms and having a population from two different clinical settings.
Following quantification, DNA samples were standardised, digested with nuclease P1 (Sigma), treated with calf intestinal phosphatase and denatured.
This finding emphasises the need for optimal dental care and standardised dental follow-up in patients treated with sunitinib.
His intention is that, from next April, specialist services will start routinely to collect standardised information on every adult they treat.
Type of surgery, locoregional radiotherapy and adjuvant systemic therapy was left to the treating physician, following nationwide standardised protocols.
The majority of patients with CD may be treated by the present investigated, standardised injection protocol.
Another reason was that a considerable proportion of patients were treated in local hospitals, making standardised treatment less likely.
The median change from baseline standardised AUC to 2 months was 0.88 for GP treated patients and −1 for GM treated patients (P=0.048, Wilcoxon rank sum test), indicating an improved quality of life for GP treated patients.
