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The authors contend that such an approach is classically used in pharmacogenetic studies where the disparate response to a standardised dose of drug provides a dynamic phenotype (high vs low metabolisers or responders vs nonresponders) from which to identify relevant genes [75].
Infiltrates were most apparent 3 and 10 days after a single standardised dose of UVB.
The antibiotic regimen was determined by the primary treating ICU physician on the basis of a standardised dose regimen, the clinical follow up and response.
GPs prescribed ACE-I to 45% of their patients and had previously initiated such treatment in an additional 3.5%, in an average standardised dose of 13.5 mg.
The GPs prescribed an ACE-I to an average of 44.9% (SD 15.9) of their CHF patients in an average standardised dose of 13.5 mg (SD 6.6).
We previously showed that induction of SBCs in the skin of patients with SLE does not differ from that in healthy controls after a single standardised dose of UVB [ 16].
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He says herbalists are promoting their individualised remedies - cocktails of up to 20 different herbs mixed for specific customers - on the back of the real evidence on the effect of standardised doses of single herbs such as St John's wort for depression.
However, this version of benzocaine is far removed from the small, standardised doses you get in dentistry – this is stuff made in bulk in bath tubs or factories in China.
Groups were treated according to a standardised dose-escalation scheme, depending on the worst toxicity experienced by patients enrolled at the prior dose level, and the clinical significance of that toxicity.
These standardised doses were then used to calculate the mean dose across all prescriptions for each patient individually.
Prospective clinical trials are warranted to investigate whether genotype-guided dosing formulas are superior to standardised dosing protocols for improved safety and cost-effectiveness of coumarin therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com