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Well-defined and documented chemistry standardisation rules applied to all compounds can greatly decrease the number of errors and expedite integration.
All standardisation rules were aligned between Janssen Pharmaceutica, AstraZeneca and IDEAConsult to reflect industry standards and implemented in open source software (https://doi.org/10.5281/zenodo.173560).org/10.5281/zenodo.173560
We have shown that a set of well-defined standardisation rules is essential while constructing systematic identifiers (can gain up to 50% increase in consistency), and that stereochemistry has an important contribution to this inconsistency.
Regenerating systematic identifiers starting from their MOL representation and applying well-defined and documented chemistry standardisation rules to all compounds prior to creating them can dramatically increase internal consistency.
KL and TC prepared the evaluation data and the AutoStan address standardisation rules.
Similar(55)
This lack of standardisation has been tackled with efforts culminating in the development of various algorithmic approaches based on the concept of distilling the process of physician review into standardised rules (42).
However, it is facing challenges, including a lack of standardisation of rules, in garnering global appeal.
Staunton and his colleagues had ambitious objectives for this tournament, including convening a "Chess Parliament" to complete the standardisation of various rules and procedures for competitive chess and for writing about chess.
It is particularly well suited to practice guidelines, organisational issues related to the standardisation of work rules and coordination, and could also be used to assess the quality of patient care pathways.
The performance of the HMM approach for name standardisation, compared to a rule-based approach, was less favourable.
However, the use of lexicon-based tokenisation combined with simple first-order HMMs as described in this paper does appear to be a viable alternative to traditional rule-based standardisation methods for more complex data such as residential addresses.
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CEO of Professional Science Editing for Scientists @ prosciediting.com