Similarly, normalization to an external RNA standard is problematic due to RNA instability.
As is common to all studies pertaining to the diagnosis of LTBI, the absence of a reliable gold standard is problematic.
Furthermore, the existence of one repeat per haplotype differing substantially in sequence from others (the "partial repeat" [ 30]) makes application of many standard methods problematic.
One of the main reasons that the implementation of these ethical standards becomes problematic in the context of biobanking is that biobanking itself differs in substantive and important ways from the more traditional models of human subjects research that the Nuremberg Code and the Declaration of Helsinki were designed to govern.
For some participants the difference in learning opportunities and standards was problematic.
Students' perception of the lack of importance of dress standards is problematic, given that evidence shows that doctors' appearance is important to patients [ 29, 30].
"In an ideal world this problematic standard would have been transitioned away from years ago".
Finally, we demonstrate that Rapamycin-induced loss of stemness can work in concert with corticosteroid, the current standard therapy for problematic hemangioma, to block hemangioma formation in vivo.
Fradkin gets to the heart of why the double standard is so problematic: "After all, what's the point of encouraging little girls to work hard in school, get good grades, apply for college, and secure a job after graduation if we then turn around and say to them, essentially, 'So, are you still planning to use all that?'".
This also raises questions about whether substituted judgment is a particularly problematic standard for students to internalize.
Thus, it is unlikely that underestimation of the standard errors is problematic.
