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For obtaining accurate relative expression magnitude, another ipath figure was generated, where the standard of change was FDR < 0.001 and the absolute value of log2Ratio ≥ 1 as mentioned above [ 21].
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SEMD was calculated from the standard deviation or standard error of change in the two arms, or from P or t values where applicable.
The mean change, standard deviation of change, standardized response mean (SRM), and the significance of the change (two sided paired t-test, without correction for multiple testing) were calculated for each measure.
* SRM: standardized response mean = magnitude of change/the standard deviation of change [ 25].
To assess responsiveness among knees with and without radiographic OA progression we calculated absolute standardized response mean (SRM) values (SRM = mean change divided by standard deviation of change).
Figure 5 Percent standard error of change estimates.
Where SD∆ is the missing standard deviation of change and R is the correlation coefficient.
For every standard deviation of change, occurrences of "intergroup conflict" rose by a whopping 14percentt, while instances of "interpersonal violence," which includes rape and domestic violence, increased by four percent.
For sample size calculation using previous data [4], the estimate of mean Ki67 expression was assumed to be 4.0% and the standard deviation of change to be 0.60.
*One standard deviation of change in biomarker score.
The standardised response mean compares change to the standard deviation of change.
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