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In recent years, ArMs have attracted increasing attention as alternatives to homogeneous catalysts (such as Rh-based hydrogenation catalysts or Os-based dihydroxylation catalysts) and naturally occurring enzymes (including variants produced by standard mutations)1,2.
Mutations in the survivors were detected phenotypically in a diagnostic phage gene, indicating that at least some of the mutagen's effect was an induction of standard mutations.
Since minisatellite mutation rates are correlated with extra-pair paternity, then standard mutations (which are often replication dependent) should show a greater effect on the expression of secondary sexual characters.
Changes in TR copy number occur 100 to 10,000 times more often than point mutations (Lynch et al. 2008), and unlike standard mutations, they often are reversible (Kashi and King 2006).
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Because the virus was part of the finch genome, they used the standard mutation rate for birds.
In normal conditions, RNA viruses also do not select mutants with lower than standard mutation rate.
These poorly-adapted populations could benefit from having higher than standard mutation rates.
As shown by various studies, age estimations using standard mutation rates must be viewed with great caution [99] [102].
Then, associated variants that do not fulfill the persistence criteria should be either susceptibility genes of exceptionally high mutation rates or resistance genes of standard mutation rates.
The mutation rates thus estimated range from 7×10−4 to 3×10−3 per locus per generation, which are standard mutation rates for microsatellite loci in other species [94].
If we assume the nuclear DNA model for schizophrenia, it should have many susceptibility genes of exceptionally high mutation rates; alternatively, it should have many disease-associated resistance genes of standard mutation rates on different chromosomes.
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