Exact(15)
Therefore, the current example suggests that including semenology as a standard endpoint in nonclinical fertility studies may be warranted.
The bioconcentration factor (BCF), as determined by OECD TG 305, is the standard endpoint in bioaccumulation assessment.
Thus, large patient numbers are needed in multicenter trials to account for such variations when the standard endpoint is symptom reporting.
Protein concentration in undiluted BALF was measured by a standard endpoint measurement at 495 nm using Bradford reagent with a bovine serum albumin standard curve (Thermo Scientific, Rockford, IL).
The base excess (BE) has become the standard endpoint of resuscitation in trauma patients.
Overall survival (OS) is the gold standard endpoint in phase III trials.
Similar(45)
Phase 1 trials use standard endpoints of safety, pharmacokinetics and limited pharmacodynamics.
The standard endpoints assessed in these protocols and how these endpoints are interpreted and translated into manifestations of toxicity are presented.
It is assumed that the criteria are relevant for the standard aquatic studies and based on standard endpoints required in such guideline tests.
As illustrated in Figure 1, the measured aquatic single-species toxicity of each product was compared with the mixture toxicity prediction calculated according to CA separately for each of six different aquatic standard endpoints used in environmental risk assessment (acute and chronic toxicity to aquatic invertebrates and fish; growth inhibition of algae and water plants).
The toxic responses of OPs on cellular and molecular level have been explored in cultured cells using standard endpoints of cytotoxicity and genotoxicity [5], [11].
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