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In addition, OS is a recognised standard end point in this setting.
To confirm target enrichment, each PCR product was evaluated first by standard end point PCR.
Modification of a clinically relevant value, which is usually the incidence of malignancy, is the standard end point.
Expression of these individual LINE-1 elements was first tested in a panel of prostate and bladder cancer cell lines using standard end point RT-PCR.
NCSs assess mostly large myelinated nerve fiber function and are still considered by most as the gold standard end point for DN in clinical trials (22).
Death from prostate cancer is the gold standard end point, which is available from few studies, with the Transatlantic Prostate Group (TAPG) study being the one with the longest follow-up.
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The purpose of measuring PROs in clinical trials alongside standard end points is to generate information to inform patients and their physicians about how treatments affect quality of life [13,14].
However, considering results of the above trials in the light of those from AMBITION, it appears that tocilizumab is the first biological agent to show statistically superior clinical efficacy using standard end points, compared with a standard methotrexate dose regimen in a 6-month study.
Standard end-point PCR was performed using QIAGEN HotStar Taq polymerase (QIAGEN Sciences, Maryland, USA).
Standard end-point and long-range PCR reactions were performed in order to amplify the specific CNV breakpoints.
Although it has never been prospectively validated, the base excess (BE) is regarded as the standard end-point of resuscitation in trauma patients.
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