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At the same time, standard drawbacks of centralized regimes apply, e.g., security and privacy concerns, computational complexity of large-scale optimization, or incentive compatibility problems may arise.
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Although the use of this standard has some drawbacks in the current application (i.e.: some loss of mapping precision), we believe this is far outweighed by its very widely accepted nature, and by the convenience and efficiency gains that it permits.
Eli Lilly & Company's experimental drug Atomoxetine treats attention deficit hyperactivity disorder in children and teenagers without some of the drawbacks of standard treatments, research has shown.
The method is intended to sidestep two major drawbacks of standard chemotherapy: the treatment's lack of specificity and the fact that cancer cells often develop resistance.
The benefits and drawbacks of standard clinical parameters and surrogate marker studies are discussed based on experience from past investigations.
The proposed approach precludes the main drawbacks of standard residual type estimators, circumvents the need of flux-equilibration and results in a simple implementation that uses standard resources available in finite element codes.
Clogging due to biomass accumulation and the loss of structural stability of the packing media are common operational drawbacks of standard gas biofiltration inherent to the traditional biofilter design, which result in prohibitive pressure drop buildups and media channeling.
Scaling problems and missing ability to display improper points as well-known drawbacks of standard conformai mapping of characteristic function are overcome by an original non-conformal mapping onto unit circle region.
In order to accurately measure CTOA of high-grade pipeline steels, a new modified compact tension (MCT) specimen was designed to alleviate the drawbacks of standard tests specimens and MDCB specimen.
However, this standard approach has several drawbacks because it can become unfeasible when too many genes are measured simultaneously.
The comparison of system versus a panel gold standard had its own drawbacks – Isabel was provided variable amount of patient detail depending on the subject who used it, while the panel were provided detailed clinical information from medical notes.
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