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Note that every symbol in the function plot corresponds to one of the 101 standard dose levels.
Dose escalation of O-LAR was associated with improved symptom control in NET patients who were refractory to the standard dose levels.
Even standard dose levels (ifosfamide 6 g m−2 and doxorubicin 60 mg m−2 and G-CSF) led to severe neutropenia in 49%, anaemia in 23%, and thrombopenia in 15% of patients (Worden et al, 2005).
As these are based on the standard dose levels (for b = 1), the designs are slightly different from the designs calculated on the transformed set of dose levels as described in " Log-logistic function" section [using (6) for transformation].
There is currently no convincing evidence demonstrating that that more dose escalated treatment regimens (e.g. high-dose chemotherapy with peripheral stem cell support) result in overall improved outcomes compared with the administration of polychemotherapy programs at standard dose levels [ 11].
It was subsequently tested in a large phase III adjuvant trial in node-positive breast cancer; the CALGB study 97-41 [ 19] compared sequential doxorubicin, paclitaxel, and cyclophosphamide at standard dose levels of 60 mg/m, 175 mg/m, and 600 mg/m, respectively, against concurrent AC, followed by paclitaxel, at the same dose levels.
Similar(54)
The dose was increased to the standard dose level in accordance with each patient's tolerance.
The top of Fig. 3 shows the single parameter variants of the designs on the standard dose level set for b = 0.5 as squares, b = 1 as solid dots and b = 2 as circles.
In addition standard exploration of dose levels, route of administration and frequency of dose are practical.
We call this dose range the standard set of dose levels.
Estimated Means and standard errors for dose levels for serum ORAC and p values for Bonferroni adjusted post hoc comparisons with baseline means presented in Table 3.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com