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Standard discontinuation criteria applied in this study: investigators could also withdraw patients from the study in the event of intercurrent illness, AEs, treatment failure, protocol violations, administrative reasons, or other reasons.
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Standard study discontinuation criteria were described in the study protocol (see Study 2 above).
Subsequently, open label infusions of sedative/analgesic agents were administered as clinically indicated and according to standard therapy following discontinuation of study opioid infusions.
Standards for the discontinuation, consolidation, or expansion of CDEs were decided on by committee consensus after discussion and review.
In this Dutch multicentre trial all patients admitted to the intensive care unit and who received antibiotics for presumed infection were assigned to a PCT-guided or standard-of-care antibiotic discontinuation.
The use of a PCT algorithm compared with standard care to guide antibiotic discontinuation in critically ill patients was evaluated in eight RCTs [23, 24, 31 34, 37, 39].
For boceprevir, detailed 4-week discontinuation rates for standard duration therapy and response-guided therapy were made available to us from two boceprevir trials.
52 Lastly, the use of perhaps all standard antidepressants is associated with discontinuation symptoms, 62 which do not seem to occur with agomelatine.
In contrast to anthracycline-related cardiotoxicity, trastuzumab-associated toxicity does not appear to be dose related, and it usually responds to standard medical treatment or the discontinuation of trastuzumab [ 30, 31].
Recommended standards of care which encourage discontinuation of medications on admission and might prompt changes in medications based on glucose control were only recently adopted [ 17].
In general, urinary tract infections responded well to standard treatment without the need for discontinuation of canagliflozin.
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