Obviously, some have thus, in the course of time, been stalled, phased out and shelved or shown to have a limited effect on distributing, retaining and motivating staff.
We assessed Rac activity in chemotaxing Rac-FRET neutrophils and found enrichment in leading-edge protrusions and unexpected longitudinal shifts and oscillations during protruding and stalling phases of migration.
During neutrophil chemotaxis, we observed unexpected behaviors of Rac activity in addition to the expected accumulation at the leading edge, including a retrograde shift during stalling phases and a yo-yoing between the front and back of the cell.
This revealed that Rac activity (normalized FRET ratio) is higher at the front of chemotaxing cells than at the back, as expected, but furthermore that the bulk of Rac activity shifts by 1.6 μm toward the posterior of the cell during stalling phases.
Because of dose limiting neurotoxicity, TNP-470 has been stalled in Phase II.
In X-linked dyskeratosis congenita, it is thought that pseudouridine-deficient ribosomes are unable to recognize IRES elements, causing a stall at M phase due to decreased translation of cell-cycle related proteins.
Because PC-3 cells are p53-negative, despite presence of extensive and severe ROS-induced DNA damage, flow-cytometric analysis indicated only a transient S-phase arrest, suggesting that the observed CA was not accompanied by prolonged S-phase stall.
After pseudobreakup (red line in both figures), there was a rapid rise of the poleward border, which then stalled until expansive phase onset (orange line in both figures).
In the absence of the intracellular domain fusion is not sustained beyond the first phase, stalling at the bi/tri nucleate precursor stage [25].
Upon RF stalling, the S phase checkpoint kinase Mec1 and the mammalian ortholog ATR exert many of their functions through the effector kinases Rad53 and CHK1, respectively.
