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Cheaters preferentially differentiate into spores while their victims die as stalk cells in chimeric aggregates.
Specification of ureteric bud tip cells distinct from ureteric stalk cells is essential for ureteric branching morphogenesis and nephrogenesis.
We defined those following ECs as stalk cells, because they eventually became stalk cells.
Instead, Dll4/Notch signaling restricts the number of stalk cells.
Tip cells and stalk cells are selected during sprouting angiogenesis.
These stalk cells are derived from dorsal extra-embryonic ectoderm.
Dll4/Notch signaling regulates the selection of single stalk cells.
Green and orange arrowheads indicate tip and stalk cells, respectively.
(E ) Schematic illustration of Ca2+-oscillatory activity in stalk cells.
Dll4 is involved in the selection of single stalk cells.
After stalk cells completely come out from the DA, strong Ca2+ oscillations occur both in tip cells and stalk cells.
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