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In case of obligate cheaters, lack of stalk cell differentiation could lead to the collapse of multicellularity17,18.
Chen, Z. H. & Schaap, P. The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium.
Dictyostelium amoebae produce a chlorinated alkyl phenone called DIF which induces stalk cell differentiation during their multicellular development.
Hopper, N. A., Anjard, C., Reymond, C. D. & Williams, J. G. Induction of terminal differentiation of Dictyostelium by cAMP- dependent protein kinase and opposing effects of intracellular and extracellular cAMP on stalk cell differentiation.
For example, stalk cell differentiation is induced by the chlorinated hexaphenone DIF-1, secreted by prespore cells, in addition to cAMP, as shown in in vitro experiments [23].
It has been suggested that DIF-1 and DIF-2 may have roles other than inducing stalk cell differentiation during the early stage of development [18].
Similar(45)
The epigenomics of embryonic stem cell differentiation.
This demonstrates stem cell differentiation into osteoblasts.
When present, p63 blocks stem cell differentiation into mature cells.
It was noted, at the early stage of the study, that the major D. discoideum genes related to stalk-cell differentiation were present in A. subglobosum despite the absence of stalk cells in this species.
Stalk and spore cell differentiation in monoloayer assays were performed at a cell density of 1×10 cells/cm (Kay, 1987) and scored by phase-contrast microscopy.
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