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Yet optimal criteria for staging, validation within a large cohort, and long-term follow-up are lacking.
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In all the aforementioned stages of filter design a two stage validation process has been followed.
As the method had to be developed a two stage validation study approach was used.
It would be a useful diagnosing tool for parameters setting, verification, and stages validation.
That's not bad going, and provides exactly the sort of early-stage validation that was hard to come by before crowd-funding.
However, very few studies evaluated the efficacy of different methods in selecting candidate SNPs for second-stage validation, invariably reporting a high percentage of false positive results.
The significantly declined level of miR-9 in NPC patients was confirmed through two-stage validation.
Conclusions:High-throughput computational analysis can provide a viable second stage validation of primary mass spectrometry database search results.
This will eventually reduce required resources in terms of time and money for biomarker discovery before early-stage validation.
Here, we report the linguistic and psychometric validation of the Welsh BDI-II and highlight the value of embedding early stage validation within the instrument development phase.
We found the significantly declined level of plasma miR-9 in NPC patients through systematic microarray-based screening and two-stage validation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com