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Knowledge about the staging significance of the prostate cancer antigen 3 (PCA3) score to better identify pathologic features after radical prostatectomy (RP) is limited and controversial.
In fact, the stratification by OCT1 level displayed even higher prognostic significance than the widely employed AJCC staging (significance p=0.0002, 5-year survival: 20 vs 42.2 months, figure 2B).
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Over subsequent stages significance levels are decreased to avoid stages becoming redundant.
Although designs (ii) and (iv) have similar overall operating characteristics, the design which uses a first stage significance level of α1=50%% (design (ii)) has a much smaller expected sample size.
Overall type I error rates, powers and correlations between stages obtained from simulations of designs (i - viii) i - viiis 2 and 3. Key: α1 = stage 1 sinnificance level, ω1 = sTables power, ρ| Hh = correlation between stages under hypothesis Hh, α = overall type I error rate, ω = overall power.
In terms of a correlation with CD168 positivity at separate clinical stages, a significance difference was only found in stages II and III.
It is important to underline that this is a pilot retrospective study and where survival trends were consistent between OS and RFS for stage stratifications, significance was not always attained when stage subgroups were analysed independently, possibly due to low patient numbers.
Most spiralian embryos exhibit tier-specific patterns of cell division at early stages; the significance of this mitotic asynchrony is unknown, but presumably reflects differential inheritance of factors regulating cell division.
Even at that stage, the significance of U-Cd on an individual basis remains uncertain.
The type of performed GSE analysis is based on the angular distance that encodes for each life cycle stage the significance of the gene set relative to the protein set.
If an interim analysis is carried out, Bonferroni corrections will be applied in the final stage (ie, significance p<0.05 will be changed to p<0.025, which will require a doubling of the number of subjects).
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