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If future larger studies confirm the predictive value of M-ficolin for early onset of sepsis, M-ficolin has potential for use as a diagnostic or staging marker.
Neopterin is an indicator of activation of the cellular immune response and has good potential not only as a staging marker but also for treatment outcome.
Future studies are needed to examine the time course of Bb changes during septic shock progression in humans to determine if Bb can serve as a staging marker of sepsis.
Based on this study, a decreased level of properdin may be a diagnostic marker for the initial stage of sepsis, and the increase in properdin levels after treatment may be a staging marker.
Among the regulatory proteins of complement, properdin was found to be decreased at the initial stage of sepsis and increased after effective treatment; thus it may have potential as a staging marker.
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The aim of the present study was to investigate eight immune-related factors, shown to be powerful markers for stratification of T. b. gambiense HAT patients [13, 15 20, 23], as staging markers for T. b. rhodesiense sleeping sickness.
Many studies have focused on the staging in T. b. gambiense HAT [13, 15 20], while less attention has been paid to T. b. rhodesiense, with a paucity of data on staging markers [13, 21, 22].
The potential of ETS2 and miR-196b as novel pathological staging markers and therapeutic targets for gastric cancer merits further investigation.
The present results show that alterations in the enzymes measured here are trait markers, whereas previous research showed that increases in TNF-α and neopterin should be regarded as staging markers [ 10].
In addition to being good staging markers, the level of these molecules seems to correlate with the severity of the neurological symptoms and therefore may assist with screening for the advanced second HAT stage [ 14].
In addition, the strong association between the loss of let-7a expression and metastatic relapse suggests the potential of let-7a in prognostic stratification of breast cancer patients in addition to conventional clinical and pathologic staging markers.
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