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Some broadly utilized staging instruments, such as the Global Deterioration Scale GDSS) or the Clinical Dementia Rating Sum of Boxes [ 2, 3], may be used to determine the patient's disease stage prior to the ROSA administration.
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A recently developed staging instrument shows much promise for monitoring patients and evaluating therapies, which at present are aimed at symptom amelioration.
OG, LS, RM were jointly responsible for devising the research protocol and conceptualization of the simplified disease staging instrument.
In this respect a vascular staging instrument may be more sensitive than diabetes duration as a proxy for health status.
GDS [ 17] – A dementia staging instrument divided into seven different stages with increasing impairment corresponding with higher stages (No Cognitive Decline, Age-Associated Memory Impairment, Mild Cognitive Impairment, Mild Dementia, Moderate Dementia, Moderately Severe Dementia, Severe Dementia).
In addition, a structured global staging instrument such as the GDS was used in the study to determine the severity stage of the patient for the use of the ROSA.
CDR [ 18] –A semi-structured, informant-based clinical staging instrument that characterizes six domains of cognitive and functional performance: Memory, Orientation, Judgment and Problem Solving, Community Affairs, Home and Hobbies, and Personal Care.
In order to allow proper interpretation of the Qualidem scores, the severity of dementia will be assessed using the Global Deterioration Scale, a staging instrument indicating cognitive deterioration in dementia [ 43].
We propose to use the diabetes vascular severity staging instrument to derive a single severity score which will be used in statistical analysis as a proxy for health status of Indigenous Australian adults with type 2 diabetes.
The simplified vascular staging instrument produced a single diabetes severity score which has shown to predict hospitalisation and mortality and can be applied using only data collected routinely in health practice settings including hospital admissions.
33 The CDR was developed as a staging instrument for dementia and is scored as no (0), questionable (0.5), mild (1), moderate (2), and severe (3) dementia, and the overall level of dementia is derived by using a standard algorithm.
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