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Often, demographic and clinical covariates are combined in a Cox model with staging information from the American Joint Committee on Cancer AJCCC) staging system to predict a patient's survival to improve treatment recommendations [ 2- 7].
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Overall, the recording of staging information improved from 1996, with the proportion of unknown stage decreasing from 36% in 1997 to 22% in 1999 then 15% in 2008.
Staging information gleaned from imaging is helpful in triaging patients to the appropriate method of therapy; in particular, imaging detection of distant metastases prevents unnecessary surgery.
In the present cohort of patients sampled within 2 months prior to cancer diagnosis, only a limited number of patients had staging information available from the Scottish Cancer Registry.
Our findings provide a method for adjusting for cancer severity when staging information is not available from national health-related databases.
Broadly consistent with the profile of cancers nationally (e.g., Morris et al, 2012), 41% of those with staging information had early stage disease but information on staging was missing from 32% of cases in our data set, which is higher than nationally.
On the first two stages information from half and full sibs on test stations is most important so that the risk of co-selecting related animals is increased.
In the first stage, information from titles and abstracts will be screened for exclusion of non-relevant retrieved papers.
Stage at diagnosis was determined using the cancer registry and/or FIGO stage information from each site (SEER guidelines: http://seer.cancer.gov/) and categorised as FIGO stage I/II (localised and regional) and FIGO stage III/IV (distant).
A 90-day cutoff was used to differentiate de novo and recurrent HER2-positive MBC, because early breast cancer staging information was missing from the records of 215 patients.
Dissections and histopathological examination of the primary tumors were done according to standard protocols for surgical pathology reports of CRCs [ 10], and additional staging information was compiled from patients' clinical charts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com