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If the local staging has demonstrated the primary tumour to be locally advanced (T3/T4), have associated extramural venous invasion or multiple involved local lymph nodes, then the probability of liver metastasis is increased and further imaging should be actively pursued for lesion characterisation.
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In recent years, dual-stage systems which incorporate serially connected fine and coarse stages have demonstrated promising results.
But he lost the stage, having demonstrated only the sort of petulance that he showed last weekend, when he complained that there were a lot of "really cool things" that he could be doing besides running for President.
Advances in interferometric observations of low-mass stars, such as AGB stars in their late evolution stages, have demonstrated the existence of shells consisting of relatively large (~300 nm) grains close (within two stellar radii) to the stars1.
Other studies of the harvesting glycolytic stage have demonstrated the effect of enzymatic inhibition of LDHA.
Recent analysis of transcript differences between two cDNA libraries from the early and late seedling developmental stages have demonstrated that a set of genes involved in starch and sucrose metabolism, and in phenylpropanoid biosynthesis may be the dominant metabolic pathways during the early stages of taproot formation in radish [ 13].
Widely used biochemical, histopathological and clinical criteria, for example prostate-specific antigen (PSA) level, Gleason score, and the clinical tumour stage, have demonstrated a significant variability in predicting subgroups of prostate cancer patients with distinct clinical outcome (Miller et al, 2001; DeMarzo et al, 2003; Glinsky et al, 2004).
Transplantation of isolated 4-cell blastomeres into morula stage embryos has demonstrated that the blastomeres at the 4-cell stage are totipotent (Kelly, 1977).
Our risk prediction score for any-stage AKI has demonstrated better discrimination compared to the Euroscore and the Cleveland Clinic Score, and equivalent discrimination to the Mehta and Ng scores.
However, a recently published SEER analysis of early-stage cHL has demonstrated that the use of RT in these patients improves overall survival (OS) without increasing the rate of second malignancies 18.
"Off-stage" Betty White also has demonstrated that she is authentically committed to meaningful values and goals; that is, she is realizing her will to meaning.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com