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For every case, data on histology, staging at presentation (based on the 2003 UICC-TNM classification [ 19] and treatment were obtained from clinical records.
When comparing staging at presentation, IMPC patients had more T3 or T4 tumours, a higher percentage of N2 or N3 nodal involvement, but had similar rates of distant metastases compared with IDC patients (2.9% vs 3.9%, P=0.19).
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This database and the files of the patients developing a malignant neoplasm, have been studied as to stage at presentation, therapy and outcome.
This suggested that the discrepancy for colonic cancer could be ascribed to later stage at presentation.
Five-year survival rates are related to stage at presentation, stage I tumours having a 67% 5-year survival, stage IV 15 19% (Peckham et al, 1995).
Increasingly the interest in the association between statin use and CRC has been with regard to stage at presentation and survival rate [ 27].
Although the overall 5-year survival from CRC is ∼60% in population-based series, prognosis is well established to be strongly linked to stage at presentation.
Prognosis was significantly correlated with stage at presentation, with those presenting early have a far better survival.
A summary of tumour and nodal stage at presentation as defined by the International Union Against Cancer TNM classification (1997) is presented in Table 1.
Nearly a half were in WHO stage III at presentation.
Factors that predict relapse include advanced stage at presentation, high-grade histology, age over 60 years and lymphovascualar invasion [24].
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