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This prevents the differential evolution from getting trapped into false maxima in the early stages of optimization.
A novel culture medium to enhance the biomass and lipid production simultaneously by Chlorella vulgaris UTEX 26 was designed in three stages of optimization.
And, the sensitivity analysis was used in the stages of optimization and post-optimization respectively.
Specifically, in early stages of optimization, audaciously modify more elements of x → in EB phase.
In the early stages of optimization, deterministic optimization is used to update the geometrical configuration to the point where the shape becomes manufacturable.
This strategy is necessary in early stages of optimization of a micromolar lead because a bivalence or fragment-based approach will be used in later stages of the optimization to take advantage of peripheral sites or exosites on the endopeptidase to achieve high affinity [12], [13], [17], [40], [41].
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At configuration level, the optimal compliant joints are used to form the parallel limbs of the multi-DOF FPM and another stage of optimization was conducted to determine the optimal space distribution between these compliant joints so as to generate a multi-DOF FPM with optimized stiffness characteristic.
At the final stage of optimization all PCBs, PHDDs and PCDFs were optimized by employing a semi-empirical Austin Model 1 (AM1) Hamiltonian with a root-mean-square gradient of 0.01 kcal/Å × mol.
The second stage of optimization was performed with preincubation of phage prior to affinity selection against target antigen.
In the first stage of optimization, the experiments were done according to the appropriate ED.
Fig. 2 Dependence of objective function (dispersion) of decomposition on the decrement k 3 at the final stage of optimization (after k 1 and k 2 were decrement).
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