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The temporal aspect has not been given explicit attention in the artificial development community, apart from defining intermediate or final stages of developmental processes, after a defined number of time steps [5].
With a few notable exceptions, human and animal model studies tend to focus on the end stages of developmental abnormalities.
Similar to the follicles beyond the germarium, cysts within the germarium are morphologically arranged in a predominately linear fashion in increasing stages of developmental maturity.
Recruitment of newly originated genes at early stages of developmental might allow evolution of specific phenotypes, while conserved genes retain function for the conserved core of development.
Studies from a number of years ago showed that the VEGF pathway is central and absolutely essential for early stages of developmental angiogenesis; these findings helped drive the development of VEGF inhibitors for clinical use (Ferrara, 1999).
However, our finding that most of the wheat NRAMP genes were not DE during wheat senescence suggests that these transporters may act in other tissues or stages of developmental stages.
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RTT girls develop normally until 6 18 months of age when they enter a stage of developmental arrest.
We speculate that the double positive subset likely corresponds to progenitors in a stage of developmental transition as this population is not retained in adult brains.
Meanwhile, Brd2-null animals survive implantation and die at a later embryonic stage of developmental abnormalities unrelated to maintenance of the inner cell mass (Shang et al., 2009), confirming our results that Brd2 is not essential for ESC state maintenance.
We found an extraordinary degree of developmental stage-specific expression of a large group of microRNAs.
Their expression is highly regulated during the developmental cycle but the role of the Adcs at the different stages of the developmental program is completely enigmatic.
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