In addition, the diagnostic performances that are quoted in the literature reflect techniques at different stages of development, making comparison of techniques challenging.
Cases solved through the use of the SNP array evaluation tool were not collected systematically, as the SNP array evaluation tool went through various stages of development, making cases hard to compare even if accrued in one institution.
Easy husbandry, large supply of eggs and transparent early stages of development make zebrafish a convenient model organism to study vertebrate development [ 7].
The presence of CD3 on the surface of all T cells at all stages of development makes it a good marker for T cells in tissue sections.
Differences observed in plasma membrane permeability to water and cryoprotectants, compared with later stages of development, makes oocyte survival rate very low with standard slow freezing protocols (Agca et al., 1998; Ford et al., 2000; Van den Abbeel et al., 2007).
First of all, the changes in DNA methylation patterns are characteristic of cancer cells, specific to the cancer type and occur at the early stages of cancer development, making them candidate biomarkers for early and specific cancer detection [6].
Lung cancer patients usually have no symptoms or have nonspecific symptoms such as shortness of breath, coughing, and weight loss at the early stage of cancer development, making early diagnosis of lung cancer extremely difficult.
In an effort to give access to cardiac fated populations at the earliest stages of development, we have made use of a transgenic mESC line (Nkx2-5-GFP) contanning an established cardiac specific enhancer element of the Nkx2-5 transcription factor [15] driving expression of the green fluorescent protein (Methods).
In the SOD1 G93A model of ALS, the differential expression of various cytoskeletal and axonal proteins at different stages of the disease development makes the interpretation of the pathogenic role of these changes rather difficult.
However, the small RNA library created for sequencing is from a single cultivar of P. vulgaris at a particular stage of development, which makes it impossible for all the predicted 208 miRNAs to be present in the sequence library.
Three clusters (metamorphic, tadpole and limb) correspond to larval stages of development that are made of eight, three and four genes, respectively (Fig. 4).
