To date no optimal 'single-stage' sensitive and specific diagnostic imaging modality, which integrates mechanical and metabolic data has been reported for this group of patients [ 1- 3, 5, 6].
Research is now directed toward finding a method of staging sensitive enough to bring the risk of occult metastases below 20%.
Initially, transgenesis and gene targeting were used to examine systemic loss-of-function and gain-of-function, respectively, but further refinements in both techniques have allowed for investigations of organ-specific, cell type-specific, developmental stage-sensitive and dose-dependent effects.
This showed that stressing the crop at flowering/middle stage is sensitive to deficit irrigation.
A. salina metanauplii were found at the life stage most sensitive to the toxic algae and hunger.
Chromosomes of this stage are sensitive to physical or chemical mutagens.
Although most MPM patients show pleural effusion at even the early stage, a sensitive diagnostic marker for MPM has not been found in the pleural effusion.
Interestingly, establishment of the TVM and maximal accumulation of DARC coincide with the parasite stage most sensitive to PF4 (trophozoites)., The intracellular fate (and function) of these imported host proteins remains to be determined.
The offspring exposed to urethane on Days 11-16, however, developed hepatomata in lower incidence than those exposed on Days 14-19, whereas the previous investigation by the author revealed that Days 11-13 correspond to the stage most sensitive to hepatocarcinogenesis.
All other antimalarial drugs in current use kill the asexual and sexual stages of sensitive P. vivax, P. malariae, P. ovale, and P. knowlesi and the asexual stages and early gametocytes (stages I to III) of sensitive P. falciparum, but they do not kill the mature P. falciparum gametocytes (stage V).
