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An interviewer administered questionnaire, the Hoehn-Yahr staging scale and the Schwab-England Activities of Daily Living Scale (SEADL) were used for assessment.

Each patient's disease severity and functional status were evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS), the modified Hoehn and Yahr Staging Scale, and the Schwab and England Activities of Daily Living Scale.

However, an additional pattern emerges from the examination of obvious outliers in the scatter plots, in particular at the genus level of the stage-scale and LVF-scale (Figs. 4a, c).

To investigate to what extent the terrestrial rock record throughout the Permian and Triassic influences the observed diversity pattern of anomodonts, the total diversity and the total diversity without singletons was divided by the number of species-informative anomodont faunas at the stage-scale and at the1-Ma-scale, respectively (Fig. 6).

Each patient's NMS, cognitive deficit, disease severity, and motor status were assessed by the Nonmotor Symptoms Scale (NMSS), Mini-Mental State Examination (MMSE), the modified Hoehn and Yahr staging scale (H&Y), and the unified Parkinson's disease rating scale part III (UPDRS III), respectively.

The fund will invest from seed and early stage, scaling up to €15 million depending on the requirements of the company.

Renal perfusion is semi-quantitatively assessed using a four-stage scale (Table 1 and Additional file 1: Figure S1a).

19 3. Moderately severe or severe dementia as classified on the Functional Assessment Staging scale (FAST) grade 6a and above.

Advanced dementia can be defined using the Functional Assessment Staging Scale (FAST) level 7 and above 16: the person cannot dress themselves, is doubly incontinent and speaks only a few words.

After a standardized neurological examination, Parkinsonian symptomatology was assessed by the motor subsection of the Unified Parkinson's Disease Rating Scale, UPDRS-motor part [ 12], and the Hoehn and Yahr staging scale [ 13].

All subjects completed the following battery of standard assessment measures: a standard demography form, the unified Parkinson's disease rating scale part III (UPDRS III- motor) [21] and the modified Hoehn and Yahr staging scale (H&Y) [22].

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