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Parry commented privately, "It seems very badly constructed for the stage, poorly conceived and the music, though clean and well-managed, is not striking or dramatic".
We have shown that VEGF-A expression is significantly associated with the tumour differentiation stage, poorly differentiated tumours expressing higher VEGF-A levels than highly differentiated tumours.
Furthermore, EGFR is overexpressed in approximately 90 100% of SCCHN specimens and has been associated with worse prognosis, including advanced stage, poorly differentiated tumours and poor survival (Santini et al 1991; Dassonville et al, 1993).
Colonic CaSR expression is detected in normal mucosa, early adenomas and polyps; it is already decreased in advanced adenomas, and is almost undetectable in late stage, poorly differentiated tumors [20 22].
Poor prognosis of SBA is associated with advanced age, pT4 tumour stage, poorly differentiated tumour, positive resection margins, lymphovascular invasion, lymph node invasion and a low number of recovery lymph nodes (Halfdanarson et al, 2010; Nicholl et al, 2010; Overman et al, 2010a).
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Patient 1 was a 75 year old female who underwent a right upper lobectomy in 2002 for a stage IIB poorly differentiated squamous cell carcinoma (T3N0MX).
BG-1 cells were derived from a patient with stage III, poorly differentiated ovarian adenocarcinoma [ 13].
In multivariate analysis, higher TNM stage and poorly differentiated histology were correlated with worse OS.
Especially, downregulation of ROBO4 and upregulation of SLIT2 mark late stage and poorly differentiated HCCs.
It remains a weakness of our data that stage was poorly recorded in 2009.
Final pathology revealed a stage IIIc poorly differentiated serous ovarian cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com