Sentence examples for stage of pathology from inspiring English sources

These techniques are promising in assisting assessment of stage of pathology and predicting PD progression.

These data are in agreement with our previous findings of a lack of neurodegeneration during the life span of our A53T-SNCA overexpressing mice [13] and suggest that these animals represent a milder form or an earlier stage of pathology compared with other SNCA-overexpressing mouse models which exhibit progressive striatal nerve terminal loss and dopaminergic axon degeneration [14], [15], [16].

Our findings show that IL-4 and IL-10 each significantly increase arginase activity in mdx muscle macrophages, although the magnitude of induction of arginase activity varied with the stage of pathology when the macrophages were collected and with the cytokine used for their stimulation.

Computer assisted image analysis, using 32 systematic random, radial sampling lines, was used for interactive measurements of distance from centre of lumen to points defining intima, media and adventitia thickness along the radial intercept, which were subsequently tabled for analysis of variance, calculations of (group –vessel) means, and related to stage of pathology.

Interestingly, LC3-II accumulation was not associated with the induction of beclin-1 (BECN-1) at this stage of pathology.

Although there is considerable evidence that inflammation leads to damage in RA joints, the link between the two processes occurs during the stage of pathology, not impairment.

Increased insight into the disease mechanism in early stages of pathology is required for the development of a successful therapy.

It is likely that similar structures are formed in neuronal and glial cells at the early stages of pathology development.

Diagnosing neurodegenerative diseases, monitoring their progression and assessing responses to treatments will all be aided by the identification of molecular markers of different stages of pathology.

With the aforementioned methodological considerations we have now demonstrated [F]FDG reductions in two transgenic models of AD and aim to further extend our findings in other models for multiple stages of pathology.

This more gradual disease progression in SOD1 G93Adl mice offers the opportunity not only to examine the very early stages of pathology, but also provides a longer therapeutic window in which the potential beneficial effects of novel agents might manifest.